Introduction
HAP-SAMPLE is a web application for simulating SNP genotypes for case-control and affected-child trio studies by resampling from Phase I/II HapMap SNP data. The user provides a list of SNPs to be "genotyped," along with a disease model file that describes causal SNPs and their effect sizes. The simulation tool is appropriate for candidate regions or whole-genome scans.


Access
Access to the simulator is now open.

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Acknowledgements
This project is supported by Grant 5-P20-RR020751-01-02 from the National Institutes of Health Center for Research Resources as part of the Carolina Center for Exploratory Genetic Analysis (CCEGA). Other sources of support include Carolina Environmental Research Center (EPA RD-83272001), NIGMS R01 GM074175, and CF Foundation Zou05P0. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH or the National Center for Research Resources.